Hui Zhang, Ph.D.
Director of Cancer Cell Proteomics, Division of Basic Science
Dr. Hui Zhang received his Ph. D. from the Johns Hopkins University School of Medicine in 1990. He was a postdoctoral associate at Harvard Medical School and the Cold Spring Harbor Laboratory from 1991-1995. In 1996, he established his own laboratory in the Department of Genetics, Yale University School of Medicine, rising to the rank of Associate Professor. He joined the Nevada Cancer Institute in July, 2007.
One of the major problems of cancer cells is their altered genetic property for growth and survival. The major research interests in Dr. Zhang’s laboratory are to elucidate the fundamental molecular mechanisms by which the cell cycle regulation, genome stability, cancer progenitor cells, and protein homeostasis are controlled and how the alterations in these regulatory processes lead to human cancer. Dr. Zhang’s laboratory has established strong and innovative research foundation for these investigations and is applying advanced technologies in proteomics and molecular genetics to identify the differences between normal and cancer cells and to establish pre-clinical disease models for mechanistic insights and for developing therapeutic strategies. Dr. Zhang’s laboratory is also actively developing approaches to translate these new findings to clinically useful applications for cancer diagnosis and treatment.
Recent publications
Higa, L. A. and Zhang, H. (2007). Stealing the Spotlight: CUL4-DDB1 Ubiquitin Ligase Docks WD40-Repeat Proteins to Destroy. Cell Division Feb 6;2(1):5.
Higa, L. A., Wu, M., Ye, T., Kobayashi, R., Sun, H., Zhang, H. (2006). CUL4/DDB1 Ubiquitin Ligase Interacts with Multiple WD40-repeat Proteins and Regulates Histone Methylation. Nature Cell Biology, 8:1277-1283.
